4fow Summary

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Crystal structure of the NanB sialidase from streptococcus pneumoniae in complex with 3-ammoniopropane-1-sulfonate

The structure was published by Brear, P., Telford, J., Taylor, G.L., and Westwood, N.J., in 2012 in a paper entitled "Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Sialidase B. This molecule has the UniProt identifier Q54727 (NANB_STRPN)search. The sample contained 697 residues which is < 90% of the natural sequence. Out of 697 residues 658 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Sialidase B Q54727 (1-697) (NANB_STRPN)search Streptococcus pneumoniae TIGR4search 100% 697 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q54727 (1 - 697) Sialidase B Streptococcus pneumoniae

Chain Structural classification (CATH) Sequence family (Pfam)
A (Q54727) Jelly Rollssearch, Neuraminidasesearch, Intramolecular Trans-sialidase; Domain 3search PF02012: BNR/Asp-box repeatsearch, PF02973: Sialidase, N-terminal domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q54727) exo-alpha-sialidase activitysearch carbohydrate metabolic processsearch

Chain InterPro annotation
A BNR repeatsearch Glycoside hydrolase, family 33, N-terminalsearch Sialidasessearch Concanavalin A-like lectin/glucanase domainsearch Trans-sialidase, domain 3search