› 4fob

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193961 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ALK tyrosine kinase receptor Chain: A
Molecule details ›
Chain: A
Length: 353 amino acids
Theoretical weight: 40.06 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UM73 (Residues: 1058-1410; Coverage: 22%)
Gene name: ALK
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 0US 1 x 0US
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 51.624Å b: 57.525Å c: 105.521Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.2 0.255
Expression system: Spodoptera frugiperda

Quick links

Citations

6 review citations

Comprehensive Review in Current Developments of Benzimidazole-Based Medicinal Chemistry.
Keri et al. (2015)
5 more

4 mentions without citation

ALK and ROS1 as a joint target for the treatment of lung cancer: a review.
Puig de la Bellacasa et al. (2013)
3 more