4fm5 Summary

pdbe.org/4fm5
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X-ray structure of des-methylflurbiprofen bound to murine COX-2

The structure was published by Windsor, M.A., Hermanson, D.J., Kingsley, P.J., et al., Banerjee, S., Sharkey, K.A., and Marnett, L.J., in 2012 in a paper entitled "Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.81 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (1-604) (PGH2_MOUSE)search Mus musculussearch 94% 604 91%
B Prostaglandin G/H synthase 2 Q05769 (1-604) (PGH2_MOUSE)search Mus musculussearch 94% 604 91%
C Prostaglandin G/H synthase 2 Q05769 (1-604) (PGH2_MOUSE)search Mus musculussearch 94% 604 91%
D Prostaglandin G/H synthase 2 Q05769 (1-604) (PGH2_MOUSE)search Mus musculussearch 94% 604 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (1 - 604) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Molecular function (GO) Biological process (GO)
A, B, C, D (Q05769) heme bindingsearch peroxidase activitysearch prostaglandin-endoperoxide synthase activitysearch regulation of blood pressuresearch oxidation-reduction processsearch prostaglandin biosynthetic processsearch response to oxidative stresssearch inflammatory responsesearch cyclooxygenase pathwaysearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search