4fkj Summary


Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

A publication describing this structure is not available. The depositing authors are Kang, Y.N.search; Stuckey, J.A.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.63 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Cyclin-dependent kinase 2. This molecule has the UniProt identifier P24941 (CDK2_HUMAN)search. The sample contained 299 residues which is 100% of the natural sequence. Out of 299 residues 277 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cyclin-dependent kinase 2 P24941 (1-298) (CDK2_HUMAN)search Homo sapienssearch 97% 299 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P24941 (1 - 298) Cyclin-dependent kinase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P24941) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P24941) protein bindingsearch cyclin-dependent protein serine/threonine kinase activitysearch kinase activitysearch protein serine/threonine kinase activitysearch histone kinase activitysearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch nucleotide bindingsearch transferase activitysearch cyclin bindingsearch ATP bindingsearch metal ion bindingsearch blood coagulationsearch regulation of ubiquitin-protein ligase activity involved in mitotic cell cyclesearch positive regulation of cell proliferationsearch mitotic nuclear divisionsearch cellular response to DNA damage stimulussearch positive regulation of DNA-dependent DNA replication initiationsearch cell cyclesearch G2/M transition of mitotic cell cyclesearch G1/S transition of mitotic cell cyclesearch protein phosphorylationsearch cell divisionsearch DNA repairsearch mitotic cell cyclesearch centrosome duplicationsearch DNA replicationsearch regulation of gene silencingsearch anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processsearch histone phosphorylationsearch potassium ion transportsearch positive regulation of transcription, DNA-templatedsearch meiotic nuclear divisionsearch cellular response to nitric oxidesearch phosphorylationsearch mitotic G1 DNA damage checkpointsearch Ras protein signal transductionsearch DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestsearch nucleoplasmsearch cytosolsearch nucleussearch cytoplasmsearch Cajal bodysearch cyclin-dependent protein kinase holoenzyme complexsearch transcription factor complexsearch X chromosomesearch cytoskeletonsearch endosomesearch Y chromosomesearch microtubule organizing centersearch centrosomesearch condensed chromosomesearch chromosome, telomeric regionsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch