› 4fg8

X-ray diffraction
2.2Å resolution

Crystal structure of human calcium/calmodulin-dependent protein kinase I 1-315 in complex with ATP

Released:
DOI: 10.2210/pdb4fg8/pdb
PDB entry 4fg8 coloured by chain, front view.
PDB entry 4fg8 coloured by chain, side view.
PDB entry 4fg8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of human CaMKIα reveal insights into the regulation mechanism of CaMKI.
Zha M, Zhong C, Ou Y, Han L, Wang J, Ding J
PLoS One 7 e44828 (2012)
PMID: 23028635

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium/calmodulin-dependent protein kinase type 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 35.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14012 (Residues: 1-315; Coverage: 85%)
Gene name: CAMK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ATP 2 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P63
Unit cell:
a: 83.415Å b: 83.415Å c: 153.372Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.248
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Cataloguing the dead: breathing new life into pseudokinase research.
Shrestha et al. (2020)
1 more

5 mentions without citation

Identification of Druggable Kinase Target Conformations Using Markov Model Metastable States Analysis of apo-Abl.
Paul et al. (2020)
4 more