4fam Summary


Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 5 in complex with 3-((3,4-dihydroisoquinolin-2(1H)-yl)sulfonyl)benzoic acid (17)

The structure was published by Jamieson, S.M., Brooke, D.G., Heinrich, D., et al., Raynham, T., Flanagan, J.U., and Denny, W.A., in 2012 in a paper entitled "3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic acids; a New Class of Highly Potent and Selective Inhibitors of the Type 5 17-beta-hydroxysteroid Dehydrogenase AKR1C3" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Aldo-keto reductase family 1 member C3.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Aldo-keto reductase family 1 member C3 P42330 (1-323) (AK1C3_HUMAN)search Homo sapienssearch 100% 331 95%
B Aldo-keto reductase family 1 member C3 P42330 (1-323) (AK1C3_HUMAN)search Homo sapienssearch 100% 331 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P42330 (1 - 323) Aldo-keto reductase family 1 member C3 Homo sapiens

Chain Sequence family (Pfam)
A, B (P42330) PF00248: Aldo/keto reductase familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P42330) geranylgeranyl reductase activitysearch dihydrotestosterone 17-beta-dehydrogenase activitysearch delta4-3-oxosteroid 5beta-reductase activitysearch oxidoreductase activitysearch testosterone 17-beta-dehydrogenase (NADP+) activitysearch prostaglandin D2 11-ketoreductase activitysearch retinol dehydrogenase activitysearch ketoreductase activitysearch prostaglandin-F synthase activitysearch oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorsearch retinal dehydrogenase activitysearch prostaglandin F receptor activitysearch 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activitysearch androsterone dehydrogenase activitysearch phenanthrene 9,10-monooxygenase activitysearch indanol dehydrogenase activitysearch testosterone dehydrogenase (NAD+) activitysearch trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activitysearch alditol:NADP+ 1-oxidoreductase activitysearch aldo-keto reductase (NADP) activitysearch ketosteroid monooxygenase activitysearch cyclooxygenase pathwaysearch renal absorptionsearch keratinocyte differentiationsearch cellular response to jasmonic acid stimulussearch arachidonic acid metabolic processsearch retinoid metabolic processsearch G-protein coupled receptor signaling pathwaysearch oxidation-reduction processsearch positive regulation of cell proliferationsearch cellular response to cadmium ionsearch small molecule metabolic processsearch cellular response to starvationsearch prostaglandin metabolic processsearch cellular response to reactive oxygen speciessearch male gonad developmentsearch cellular response to calcium ionsearch daunorubicin metabolic processsearch positive regulation of protein kinase B signalingsearch farnesol catabolic processsearch cellular response to corticosteroid stimulussearch progesterone metabolic processsearch positive regulation of reactive oxygen species metabolic processsearch cellular response to prostaglandin stimulussearch negative regulation of retinoic acid biosynthetic processsearch response to prostaglandinsearch positive regulation of endothelial cell apoptotic processsearch steroid metabolic processsearch regulation of testosterone biosynthetic processsearch multicellular organismal macromolecule metabolic processsearch phototransduction, visible lightsearch protein import into nucleus, translocationsearch regulation of retinoic acid receptor signaling pathwaysearch testosterone biosynthetic processsearch response to nutrientsearch retinal metabolic processsearch positive regulation of cell deathsearch doxorubicin metabolic processsearch extracellular vesicular exosomesearch cytoplasmsearch intracellularsearch cytosolsearch nucleussearch

Chain InterPro annotation
A, B Aldo/keto reductasesearch Aldo/keto reductase, conserved sitesearch Aldo/keto reductase subgroupsearch NADP-dependent oxidoreductase domainsearch