EC 1.1.1.64: Testosterone 17-beta-dehydrogenase (NADP(+))
Reaction catalysed:
Testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH
Systematic name:
17-beta-hydroxysteroid:NADP(+) 17-oxidoreductase
Alternative Name(s):
- 17-ketoreductase
- NADP-dependent testosterone-17-beta-oxidoreductase
EC 1.1.1.62: 17-beta-estradiol 17-dehydrogenase
Reaction catalysed:
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H
Systematic name:
17-beta-estradiol:NAD(P)(+) 17-oxidoreductase
Alternative Name(s):
- 17-beta,20-alpha-hydroxysteroid dehydrogenase
- 17-beta-HSD
- 17-beta-estradiol dehydrogenase
- 17-beta-hydroxysteroid dehydrogenase
- 20-alpha-hydroxysteroid dehydrogenase
- Estradiol dehydrogenase
- Estrogen 17-oxidoreductase
- HSD17B7
EC 1.1.1.53: 3-alpha(or 20-beta)-hydroxysteroid dehydrogenase
Reaction catalysed:
Androstan-3-alpha,17-beta-diol + NAD(+) = 17-beta-hydroxyandrostan-3-one + NADH
Systematic name:
3-alpha(or 20-beta)-hydroxysteroid:NAD(+) oxidoreductase
Alternative Name(s):
- (R)-20-hydroxysteroid dehydrogenase
- 20-beta-HSD
- 20-beta-hydroxysteroid dehydrogenase
- 3-alpha,20-beta-hydroxysteroid:NAD(+)-oxidoreductase
- Cortisone reductase
- Dehydrogenase, 20-beta-hydroxy steroid
- Delta(4)-3-ketosteroid hydrogenase
- NADH-20-beta-hydroxysteroid dehydrogenase
EC 1.1.1.357: 3-alpha-hydroxysteroid 3-dehydrogenase
Reaction catalysed:
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H
Systematic name:
3-alpha-hydroxysteroid:NAD(P)(+) 3-oxidoreductase
Alternative Name(s):
- 3-alpha-hydroxysteroid dehydrogenase
- AKR1C2 (gene name)
- AKR1C4 (gene name)
- HsdA (gene name)
EC 1.1.1.239: 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))
Reaction catalysed:
Testosterone + NAD(+) = androstenedione + NADH
Systematic name:
3-alpha(or 17-beta)-hydroxysteroid:NAD(+) oxidoreductase
Alternative Name(s):
- 17-beta-HSD
- 17-ketoreductase
- 3-alpha(17-beta)-HSD
- 3-alpha,17-beta-hydroxy steroid dehydrogenase
- HSD17B6 (gene name)
- HSD17B8 (gene name)
EC 1.1.1.210: 3-beta-(or 20-alpha)-hydroxysteroid dehydrogenase
Reaction catalysed:
5-alpha-androstan-3-beta,17-beta-diol + NADP(+) = 17-beta-hydroxy-5-alpha-androstan-3-one + NADPH
Systematic name:
3-beta(or 20-alpha)-hydroxysteroid:NADP(+) oxidoreductase
Alternative Name(s):
- 3-beta,20-alpha-hydroxysteroid oxidoreductase
- 3-beta-HSD
- Dehydrogenase, 3-beta,20-alpha-hydroxy steroid
- Progesterone reductase
EC 1.1.1.188: Prostaglandin-F synthase
Reaction catalysed:
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADPH
Systematic name:
(5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 11-oxidoreductase
Alternative Name(s):
- NADPH-dependent prostaglandin D(2) 11-keto reductase
- PGD(2) 11-ketoreductase
- PGF synthetase
- PGF(2)-alpha synthetase
- Prostaglandin 11-keto reductase
- Prostaglandin 11-ketoreductase
- Prostaglandin D(2)-ketoreductase
- Prostaglandin F synthase
- Prostaglandin F synthetase
- Prostaglandin-D(2) 11-ketoreductase
- Prostaglandin-D(2) 11-reductase
- Prostaglandin-D(2) ketoreductase
- Prostaglandin-F synthetase
- Reductase, 15-hydroxy-11-oxoprostaglandin
- Synthetase, prostaglandin F(2)-alpha
GO terms
Biochemical function:
- all-trans-retinol dehydrogenase (NADP+) activity
- delta4-3-oxosteroid 5beta-reductase activity
- ketosteroid monooxygenase activity
- testosterone 17-beta-dehydrogenase (NADP+) activity
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- testosterone dehydrogenase (NAD+) activity
- 5alpha-androstane-3beta,17beta-diol dehydrogenase activity
- androsterone dehydrogenase activity
- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
- prostaglandin-F synthase activity
- ketoreductase activity
- geranylgeranyl reductase activity
- prostaglandin D2 11-ketoreductase activity
- prostaglandin H2 endoperoxidase reductase activity
- dihydrotestosterone 17-beta-dehydrogenase activity
- bile acid binding
- phenanthrene 9,10-monooxygenase activity
- oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
- oxidoreductase activity
- all-trans-retinol dehydrogenase (NAD+) activity
- estradiol 17-beta-dehydrogenase [NAD(P)] activity
- aldo-keto reductase (NADPH) activity
- aldose reductase (NADPH) activity
- retinal dehydrogenase activity
Biological process:
- positive regulation of reactive oxygen species metabolic process
- positive regulation of endothelial cell apoptotic process
- regulation of testosterone biosynthetic process
- negative regulation of retinoic acid biosynthetic process
- cellular response to prostaglandin D stimulus
- cellular response to jasmonic acid stimulus
- cellular response to corticosteroid stimulus
- cellular response to prostaglandin stimulus
- cellular response to calcium ion
- renal absorption
- testosterone biosynthetic process
- positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- regulation of retinoic acid receptor signaling pathway
- doxorubicin metabolic process
- daunorubicin metabolic process
- macromolecule metabolic process
- retinal metabolic process
- retinol metabolic process
- progesterone metabolic process
- keratinocyte differentiation
- cyclooxygenase pathway
- farnesol catabolic process
- cellular response to starvation
- male gonad development
- positive regulation of cell population proliferation
- steroid metabolic process
- response to nutrient
- G protein-coupled receptor signaling pathway
- prostaglandin metabolic process
- lipid metabolic process
- retinoid metabolic process
Protein family (Pfam)
InterPro annotations
CATH domain