4faa Summary

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Structure of Recombinant Cytochrome ba3 Oxidase mutant A120F+A204F from Thermus thermophilus

We have no information on the publication of this entry. The depositing authors are Li, Y.search; Chen, Y.search; Stout, C.D.search

This crystal structure was determined using X-ray diffraction at a resolution of 2.8 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Cytochrome c oxidase subunit 1, Cytochrome c oxidase subunit 2, and Cytochrome c oxidase polypeptide 2A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Cytochrome c oxidase subunit 1 Q5SJ79 (2-562) (COX1_THET8)search Thermus thermophilus HB8search 100% 568 94%
B Cytochrome c oxidase subunit 2 Q5SJ80 (1-168) (COX2_THET8)search Thermus thermophilus HB8search 99% 168 98%
C Cytochrome c oxidase polypeptide 2A P82543 (1-34) (COXA_THET8)search Thermus thermophilus HB8search 97% 34 91%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q5SJ79 (2 - 562) Cytochrome c oxidase subunit 1 Thermus thermophilus HB8
Q5SJ80 (1 - 168) Cytochrome c oxidase subunit 2 Thermus thermophilus HB8
P82543 (1 - 34) Cytochrome c oxidase polypeptide 2A Thermus thermophilus HB8

Chain Sequence family (Pfam)
A (Q5SJ79) PF00115: Cytochrome C and Quinol oxidase polypeptide Isearch
B (Q5SJ80) PF00116: Cytochrome C oxidase subunit II, periplasmic domainsearch, PF09125: Cytochrome C oxidase subunit II, transmembranesearch
C (P82543) PF08113: Cytochrome c oxidase subunit IIa familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q5SJ79) heme bindingsearch cytochrome-c oxidase activitysearch electron carrier activitysearch iron ion bindingsearch oxidoreductase activitysearch metal ion bindingsearch proton transportsearch oxidation-reduction processsearch aerobic respirationsearch oxidative phosphorylationsearch ion transportsearch hydrogen ion transmembrane transportsearch integral component of membranesearch plasma membranesearch membranesearch respiratory chainsearch
B (Q5SJ80) cytochrome-c oxidase activitysearch copper ion bindingsearch oxidoreductase activitysearch metal ion bindingsearch electron transport chainsearch oxidation-reduction processsearch hydrogen ion transmembrane transportsearch integral component of membranesearch membranesearch plasma membranesearch respiratory chainsearch
C (P82543) cytochrome-c oxidase activitysearch oxidoreductase activitysearch proton transportsearch oxidation-reduction processsearch ion transportsearch hydrogen ion transmembrane transportsearch plasma membranesearch respiratory chainsearch integral component of membranesearch membranesearch

Chain InterPro annotation
A Cytochrome c oxidase subunit Isearch Cytochrome c oxidase, subunit I, copper-binding sitesearch Cytochrome c oxidase, subunit I domainsearch
B Copper centre Cu(A)search Cytochrome c oxidase subunit II C-terminalsearch Cupredoxinsearch Cytochrome C oxidase subunit II, transmembrane domainsearch Cytochrome C oxidase subunit IIa, transmembrane domainsearch GPCR, rhodopsin-like, 7TMsearch
C Cytochrome c oxidase polypeptide 2Asearch