4f9o Summary


Crystal Structure of recombinant human Hexokinase type I with 2-deoxy-Glucose 6-Phosphate

The structure was published by Shen, L., Gao, Y., and Honzatko, R.B., in in a paper entitled "Inhibitor Sites of Unequal Affinity Linked by Binding Synergism in Mutant Forms of Recombinant Human Hexokinase Type-I" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.65 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Hexokinase-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hexokinase-1 P19367 (1-914) (HXK1_HUMAN)search Homo sapienssearch 100% 914 98%
B Hexokinase-1 P19367 (1-914) (HXK1_HUMAN)search Homo sapienssearch 100% 914 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P19367 (1 - 914) Hexokinase-1 Homo sapiens

Chain Sequence family (Pfam)
A, B (P19367) PF00349: Hexokinasesearch, PF03727: Hexokinasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P19367) ATP bindingsearch catalytic activitysearch fructokinase activitysearch protein bindingsearch hexokinase activitysearch phosphotransferase activity, alcohol group as acceptorsearch glucokinase activitysearch mannokinase activitysearch transferase activitysearch nucleotide bindingsearch kinase activitysearch mitochondrial outer membranesearch cytosolsearch membranesearch mitochondrionsearch glucose transportsearch carbohydrate phosphorylationsearch metabolic processsearch hexose metabolic processsearch small molecule metabolic processsearch glycolytic processsearch carbohydrate metabolic processsearch cell deathsearch glucose 6-phosphate metabolic processsearch transmembrane transportsearch cellular glucose homeostasissearch hexose transportsearch phosphorylationsearch

Chain InterPro annotation
A, B Hexokinasesearch Hexokinase, conserved sitesearch Hexokinase, N-terminalsearch Hexokinase, C-terminalsearch