› 4f7o

X-ray diffraction
2.6Å resolution

Crystal structure of CSN5

Released:
DOI: 10.2210/pdb4f7o/pdb
PDB entry 4f7o coloured by chain, front view.
PDB entry 4f7o coloured by chain, side view.
PDB entry 4f7o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Insights into the regulation of the human COP9 signalosome catalytic subunit, CSN5/Jab1.
Echalier A, Pan Y, Birol M, Tavernier N, Pintard L, Hoh F, Ebel C, Galophe N, Claret FX, Dumas C
Proc Natl Acad Sci U S A 110 1273-8 (2013)
PMID: 23288897

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-187810 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
COP9 signalosome complex subunit 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92905 (Residues: 1-257; Coverage: 77%)
Gene names: COPS5, CSN5, JAB1
Sequence domains: JAB1/Mov34/MPN/PAD-1 ubiquitin protease
Structure domains: Cytidine Deaminase, domain 2

Ligands and Environments

2 bound ligands:
Ligand ZN 2 x ZN
Ligand SCN 3 x SCN
1 modified residue:
Ligand MSE 22 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 161.734Å b: 46.505Å c: 71.261Å
α: 90° β: 100.27° γ: 90°
R-values:
R R work R free
0.219 0.216 0.274
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Protein neddylation: beyond cullin-RING ligases.
Enchev et al. (2015)
14 more

11 mentions without citation

Regulation of proteolysis by human deubiquitinating enzymes.
Eletr et al. (2014)
10 more