4ezl Summary


Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf

The structure was published by Sutherlin, D.P., Baker, S., Bisconte, A., et al., Ultsch, M., Waszkowycz, B., and Wei, B., in 2012 in a paper entitled "Potent and selective inhibitors of PI3K-delta: obtaining isoform selectivity from the affinity pocket and tryptophan shelf" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.94 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. This molecule has the UniProt identifier P48736 (PK3CG_HUMAN)search. The sample contained 966 residues which is < 90% of the natural sequence. Out of 966 residues 831 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform P48736 (144-1102) (PK3CG_HUMAN)search Homo sapienssearch < 90% 966 86%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P48736 (144 - 1102) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens

Chain Sequence family (Pfam)
A Phosphatidylinositol 3- and 4-kinasesearch, Phosphoinositide 3-kinase family, accessory domain (PIK domain)search, Phosphoinositide 3-kinase C2search, PI3-kinase family, ras-binding domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P48736) phosphotransferase activity, alcohol group as acceptorsearch transferase activity, transferring phosphorus-containing groupssearch phosphatidylinositol-mediated signalingsearch phosphatidylinositol phosphorylationsearch

Chain InterPro annotation
A C2 domainsearch Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainsearch Phosphatidylinositol 3-/4-kinase, catalytic domainsearch Phosphoinositide 3-kinase, accessory (PIK) domainsearch Phosphatidylinositol 3-kinase, C2 domainsearch Protein kinase-like domainsearch Phosphatidylinositol Kinasesearch Armadillo-type foldsearch Phosphatidylinositol 3/4-kinase, conserved sitesearch Ubiquitin-related domainsearch