› 4ez5

X-ray diffraction
2.7Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 6 Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q00534 (Residues: 1-301; Coverage: 92%)
Gene names: CDK6, CDKN6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 0RS 1 x 0RS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I4
Unit cell:
a: 102.478Å b: 102.478Å c: 59.987Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.216 0.287
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.
Sánchez-Martínez et al. (2015)
4 more

8 mentions without citation

Targeting CDK6 in cancer: State of the art and new insights.
Tadesse et al. (2015)
7 more