4eyw Summary


Crystal structure of rat carnitine palmitoyltransferase 2 in complex with 1-[(R)-2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-piperidin-1-yl]-2-phenoxy-ethanone

The structure was published by Perspicace, S., Rufer, A.C., Thoma, R., et al., Ceccarelli, S., Schulz-Gasch, T., and Seelig, J., in 2013 in a paper entitled "Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.885 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Carnitine O-palmitoyltransferase 2, mitochondrial.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carnitine O-palmitoyltransferase 2, mitochondrial P18886 (27-658) (CPT2_RAT)search Rattus norvegicussearch 95% 634 100%
B Carnitine O-palmitoyltransferase 2, mitochondrial P18886 (27-658) (CPT2_RAT)search Rattus norvegicussearch 95% 634 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P18886 (27 - 658) Carnitine O-palmitoyltransferase 2, mitochondrial Rattus norvegicus

Chain Sequence family (Pfam)
A, B (P18886) PF00755: Choline/Carnitine o-acyltransferasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P18886) transferase activity, transferring acyl groupssearch carnitine O-palmitoyltransferase activitysearch transferase activitysearch mitochondrionsearch mitochondrial inner membranesearch membranesearch fatty acid beta-oxidationsearch lipid metabolic processsearch fatty acid metabolic processsearch long-chain fatty acid transportsearch transportsearch

Chain InterPro annotation
A, B Acyltransferase ChoActase/COT/CPTsearch