› 4esr

X-ray diffraction
1.53Å resolution

Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors

Released:
DOI: 10.2210/pdb4esr/pdb
PDB entry 4esr coloured by chain, front view.
PDB entry 4esr coloured by chain, side view.
PDB entry 4esr coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors.
Liu X, Chen M, Lobo P, An J, Grace Cheng SW, Moradian A, Morin GB, Van Petegem F, Jiang X
Proteomics 12 2094-106 (2012)
PMID: 22623184

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185352 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Jouberin Chains: A, B
Molecule details ›
Chains: A, B
Length: 69 amino acids
Theoretical weight: 7.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N157 (Residues: 1048-1116; Coverage: 6%)
Gene name: AHI1
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

1 bound ligand:
Ligand PEG 3 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P41212
Unit cell:
a: 68.142Å b: 68.142Å c: 98.489Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.125 0.124 0.139
Expression system: Escherichia coli

Quick links

Citations

3 citation in other articles

Annexin A2 could enhance multidrug resistance by regulating NF-κB signaling pathway in pediatric neuroblastoma.
Wang et al. (2017)
2 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)