4ep9 Summary

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CRYSTAL STRUCTURE OF RAT CARNITINE PALMITOYLTRANSFERASE 2 IN COMPLEX WITH CoA-site inhibitor

The structure was published by Perspicace, S., Rufer, A.C., Thoma, R., et al., Ceccarelli, S., Schulz-Gasch, T., and Seelig, J., in 2013 in a paper entitled "Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.03 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carnitine O-palmitoyltransferase 2, mitochondrial. This molecule has the UniProt identifier P18886 (CPT2_RAT)search. The sample contained 653 residues which is 96% of the natural sequence. Out of 653 residues 625 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carnitine O-palmitoyltransferase 2, mitochondrial P18886 (27-658) (CPT2_RAT)search Rattus norvegicussearch 95% 653 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P18886 (27 - 658) Carnitine O-palmitoyltransferase 2, mitochondrial Rattus norvegicus

Chain Sequence family (Pfam)
A (P18886) PF00755: Choline/Carnitine o-acyltransferasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P18886) mitochondrial inner membranesearch membranesearch mitochondrionsearch transferase activity, transferring acyl groupssearch carnitine O-palmitoyltransferase activitysearch transferase activitysearch transportsearch lipid metabolic processsearch long-chain fatty acid transportsearch fatty acid beta-oxidationsearch fatty acid metabolic processsearch

Chain InterPro annotation
A Acyltransferase ChoActase/COT/CPTsearch