4ehp Summary


Crystal Structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin (residues 277-382)

The structure was published by Rangarajan, E.S. and Izard, T., in 2012 in a paper entitled "alpha-Catenin unfurls upon binding to vinculin" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.66 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vinculin and Catenin alpha-1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vinculin P18206 (1-252) (VINC_HUMAN)search Homo sapienssearch 94% 253 98%
B Catenin alpha-1 P35221 (277-382) (CTNA1_HUMAN)search Homo sapienssearch 91% 111 83%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18206 (1 - 252) Vinculin Homo sapiens
P35221 (277 - 382) Catenin alpha-1 Homo sapiens

Chain Sequence family (Pfam)
A (P18206) PF01044: Vinculin familysearch
B (P35221) PF01044: Vinculin familysearch
Chain InterPro annotation
A Vinculin, conserved sitesearch Vinculin/alpha-cateninsearch
B Alpha-cateninsearch Vinculin/alpha-cateninsearch