4eh5 Summary


Human p38 MAP kinase in complex with NP-F4 and RL87

The structure was published by Over, B., Wetzel, S., Grutter, C., et al., Renner, S., Rauh, D., and Waldmann, H., in 2012 in a paper entitled "Natural-product-derived fragments for fragment-based ligand discovery." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 327 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 91%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Sequence family (Pfam)
A (Q16539) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch ATP bindingsearch protein bindingsearch kinase activitysearch MAP kinase activitysearch nucleotide bindingsearch protein serine/threonine kinase activitysearch NFAT protein bindingsearch transferase activitysearch MAP kinase kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch toll-like receptor signaling pathwaysearch toll-like receptor 2 signaling pathwaysearch chemotaxissearch innate immune responsesearch MyD88-dependent toll-like receptor signaling pathwaysearch RNA metabolic processsearch Ras protein signal transductionsearch signal transduction in response to DNA damagesearch positive regulation of protein import into nucleussearch osteoclast differentiationsearch toll-like receptor 9 signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch vascular endothelial growth factor receptor signaling pathwaysearch response to stresssearch response to muramyl dipeptidesearch positive regulation of myotube differentiationsearch positive regulation of reactive oxygen species metabolic processsearch positive regulation of blood vessel endothelial cell migrationsearch blood coagulationsearch toll-like receptor 4 signaling pathwaysearch DNA damage checkpointsearch striated muscle cell differentiationsearch positive regulation of myoblast fusionsearch toll-like receptor TLR6:TLR2 signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch intracellular signal transductionsearch cellular response to lipopolysaccharidesearch toll-like receptor 5 signaling pathwaysearch peptidyl-serine phosphorylationsearch fatty acid oxidationsearch activation of MAPK activitysearch toll-like receptor 10 signaling pathwaysearch gene expressionsearch cartilage condensationsearch chondrocyte differentiationsearch signal transductionsearch cell surface receptor signaling pathwaysearch p38MAPK cascadesearch positive regulation of myoblast differentiationsearch response to lipopolysaccharidesearch cellular response to DNA damage stimulussearch neurotrophin TRK receptor signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch positive regulation of erythrocyte differentiationsearch MyD88-independent toll-like receptor signaling pathwaysearch stress-activated MAPK cascadesearch regulation of transcription from RNA polymerase II promotersearch phosphorylationsearch cellular component movementsearch mRNA metabolic processsearch angiogenesissearch stress-induced premature senescencesearch apoptotic processsearch 3'-UTR-mediated mRNA stabilizationsearch positive regulation of transcription from RNA polymerase II promotersearch glucose metabolic processsearch TRIF-dependent toll-like receptor signaling pathwaysearch MAPK cascadesearch transcription, DNA-templatedsearch platelet activationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch regulation of transcription, DNA-templatedsearch toll-like receptor 3 signaling pathwaysearch positive regulation of muscle cell differentiationsearch cellular response to ionizing radiationsearch skeletal muscle tissue developmentsearch cell morphogenesissearch muscle cell differentiationsearch cellular response to vascular endothelial growth factor stimulussearch extracellular vesicular exosomesearch nucleussearch cytosolsearch nucleoplasmsearch mitochondrionsearch cytoplasmsearch cellsearch spindle polesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch