4eh2 Summary


Human p38 MAP kinase in complex with NP-F1 and RL87

The structure was published by Over, B., Wetzel, S., Grutter, C., et al., Renner, S., Rauh, D., and Waldmann, H., in 2012 in a paper entitled "Natural-product-derived fragments for fragment-based ligand discovery." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Mitogen-activated protein kinase 14. This molecule has the UniProt identifier Q16539 (MK14_HUMAN)search. The sample contained 360 residues which is 100% of the natural sequence. Out of 360 residues 334 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Mitogen-activated protein kinase 14 Q16539 (2-360) (MK14_HUMAN)search Homo sapienssearch 97% 360 93%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q16539 (2 - 360) Mitogen-activated protein kinase 14 Homo sapiens

Chain Sequence family (Pfam)
A (Q16539) PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q16539) protein kinase activitysearch protein bindingsearch protein serine/threonine kinase activitysearch ATP bindingsearch NFAT protein bindingsearch MAP kinase kinase activitysearch MAP kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch kinase activitysearch nucleotide bindingsearch transferase activitysearch toll-like receptor signaling pathwaysearch innate immune responsesearch DNA damage checkpointsearch positive regulation of myotube differentiationsearch positive regulation of transcription from RNA polymerase II promotersearch regulation of transcription from RNA polymerase II promotersearch p38MAPK cascadesearch toll-like receptor 5 signaling pathwaysearch stress-induced premature senescencesearch toll-like receptor 4 signaling pathwaysearch muscle cell differentiationsearch peptidyl-serine phosphorylationsearch response to lipopolysaccharidesearch MyD88-independent toll-like receptor signaling pathwaysearch positive regulation of myoblast fusionsearch cellular response to DNA damage stimulussearch apoptotic processsearch skeletal muscle tissue developmentsearch 3'-UTR-mediated mRNA stabilizationsearch signal transductionsearch mRNA metabolic processsearch osteoclast differentiationsearch protein phosphorylationsearch phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch toll-like receptor 9 signaling pathwaysearch platelet activationsearch cellular response to lipopolysaccharidesearch MyD88-dependent toll-like receptor signaling pathwaysearch glucose metabolic processsearch RNA metabolic processsearch positive regulation of protein import into nucleussearch intracellular signal transductionsearch toll-like receptor 2 signaling pathwaysearch negative regulation of canonical Wnt signaling pathwaysearch chondrocyte differentiationsearch transcription, DNA-templatedsearch gene expressionsearch positive regulation of myoblast differentiationsearch cartilage condensationsearch blood coagulationsearch positive regulation of blood vessel endothelial cell migrationsearch response to muramyl dipeptidesearch fatty acid oxidationsearch Ras protein signal transductionsearch myoblast differentiation involved in skeletal muscle regenerationsearch cellular component movementsearch toll-like receptor 10 signaling pathwaysearch response to stresssearch activation of MAPK activitysearch angiogenesissearch regulation of transcription, DNA-templatedsearch stress-activated MAPK cascadesearch positive regulation of erythrocyte differentiationsearch vascular endothelial growth factor receptor signaling pathwaysearch toll-like receptor TLR1:TLR2 signaling pathwaysearch regulation of sequence-specific DNA binding transcription factor activitysearch cell morphogenesissearch toll-like receptor 3 signaling pathwaysearch cellular response to vascular endothelial growth factor stimulussearch striated muscle cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch TRIF-dependent toll-like receptor signaling pathwaysearch lipopolysaccharide-mediated signaling pathwaysearch positive regulation of reactive oxygen species metabolic processsearch cellular response to ionizing radiationsearch cell surface receptor signaling pathwaysearch toll-like receptor TLR6:TLR2 signaling pathwaysearch chemotaxissearch signal transduction in response to DNA damagesearch positive regulation of muscle cell differentiationsearch nucleoplasmsearch cytosolsearch cellsearch cytoplasmsearch mitochondrionsearch nucleussearch spindle polesearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Mitogen-activated protein (MAP) kinase, conserved sitesearch Mitogen-activated protein (MAP) kinase, p38search Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch