4eef

X-ray diffraction
2.7Å resolution

Crystal structure of the designed inhibitor protein F-HB80.4 in complex with the 1918 influenza virus hemagglutinin.

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero nonamer
PDBe Complex ID:
PDB-CPX-164433 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Hemagglutinin HA1 chain Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 331 amino acids
Theoretical weight: 36.45 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9WFX3 (Residues: 14-344; Coverage: 60%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:
Hemagglutinin HA2 chain Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 179 amino acids
Theoretical weight: 20.39 KDa
Source organism: Influenza A virus (A/Brevig Mission/1/1918(H1N1))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9WFX3 (Residues: 345-520; Coverage: 32%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains: Hemagglutinin Ectodomain; Chain B
F-HB80.4, DESIGNED HEMAGGLUTININ BINDING PROTEIN Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 74 amino acids
Theoretical weight: 8.81 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Structure domains: Homeodomain-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P212121
Unit cell:
a: 72.333Å b: 126.151Å c: 243.29Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.229 0.285
Expression systems:
  • Trichoplusia ni
  • Escherichia coli