4ec0 Summary


Crystal structure of hH-PGDS with water displacing inhibitor

The structure was published by Trujillo, J.I., Kiefer, J.R., Huang, W., et al., Wynn, T.A., Carron, C.P., and Thorarensen, A., in 2012 in a paper entitled "Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Hematopoietic prostaglandin D synthase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hematopoietic prostaglandin D synthase O60760 (1-199) (HPGDS_HUMAN)search Homo sapienssearch 99% 200 100%
B Hematopoietic prostaglandin D synthase O60760 (1-199) (HPGDS_HUMAN)search Homo sapienssearch 99% 200 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O60760 (1 - 199) Hematopoietic prostaglandin D synthase Homo sapiens

Chain Sequence family (Pfam)
A, B (O60760) PF00043: Glutathione S-transferase, C-terminal domainsearch, PF02798: Glutathione S-transferase, N-terminal domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (O60760) small molecule metabolic processsearch arachidonic acid metabolic processsearch prostaglandin metabolic processsearch lipid metabolic processsearch locomotory behaviorsearch fatty acid biosynthetic processsearch fatty acid metabolic processsearch prostaglandin biosynthetic processsearch cyclooxygenase pathwaysearch xenobiotic metabolic processsearch signal transductionsearch glutathione derivative biosynthetic processsearch isomerase activitysearch protein homodimerization activitysearch metal ion bindingsearch magnesium ion bindingsearch calcium ion bindingsearch prostaglandin-D synthase activitysearch glutathione transferase activitysearch transferase activitysearch cytoplasmsearch cytosolsearch

Chain InterPro annotation
A, B Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, C-terminalsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch