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Crystal structure of hH-PGDS with water displacing inhibitor

X-ray diffraction
1.85Å resolution
PDB entry 4ec0 coloured by chain, front view.
PDB entry 4ec0 coloured by chain, side view.
PDB entry 4ec0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hematopoietic prostaglandin D synthase
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Multimeric state: homo dimer
Accessible surface area: 18548.4 Å2
Buried surface area: 4206.76 Å2
Dissociation area: 83.77 Å2
Dissociation energy (ΔGdiss): 10.55 kcal/mol
Dissociation entropy (TΔSdiss): -1.46 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-130086

Macromolecules

Hematopoietic prostaglandin D synthase
Chains: A, B
Length: 200 amino acids
Theoretical weight: 23.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60760 (Residues: 1-199; Coverage: 100%)
Gene names: GSTS, HPGDS, PGDS, PTGDS2
Pfam:
InterPro:
CATH:
Hematopoietic prostaglandin D synthase in PDB entry 4ec0, assembly 1, front view.
Hematopoietic prostaglandin D synthase in PDB entry 4ec0, assembly 1, side view.
Hematopoietic prostaglandin D synthase in PDB entry 4ec0, assembly 1, top view.
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