› 4ea3

X-ray diffraction
3.01Å resolution

Structure of the N/OFQ Opioid Receptor in Complex with a Peptide Mimetic

Released:
DOI: 10.2210/pdb4ea3/pdb
PDB entry 4ea3 coloured by chain, front view.
PDB entry 4ea3 coloured by chain, side view.
PDB entry 4ea3 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic.
Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC
Nature 485 395-9 (2012)
PMID: 22596163

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142086 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nociceptin receptor; Soluble cytochrome b562 Chains: A, B
Molecule details ›
Chains: A, B
Length: 434 amino acids
Theoretical weight: 48.08 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P0ABE7 (Residues: 23-128; Coverage: 100%)
  • Canonical: P41146 (Residues: 43-339; Coverage: 80%)
Gene names: OOR, OPRL1, ORL1, cybC
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand 0NN 2 x 0NN
Ligand OLB 1 x OLB
Ligand OLA 1 x OLA
Ligand OLC 1 x OLC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P21
Unit cell:
a: 42.106Å b: 170.939Å c: 65.353Å
α: 90° β: 103.14° γ: 90°
R-values:
R R work R free
0.25 0.248 0.288
Expression system: Spodoptera frugiperda

Quick links

Citations

113 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
112 more

76 mentions without citation

The GPCR Network: a large-scale collaboration to determine human GPCR structure and function.
Stevens et al. (2013)
75 more