4e5q Summary

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Human Carbonic Anhydrase II in complex with cyanate

A publication describing this structure is not available. The depositing authors are West, D.search; McKenna, R.search

This crystal structure was determined using X-ray diffraction at a resolution of 1.7024 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) apical part of cellsearch plasma membranesearch cytosolsearch cytoplasmsearch microvillussearch myelin sheathsearch basolateral plasma membranesearch extracellular vesicular exosomesearch membranesearch extracellular spacesearch axonsearch positive regulation of synaptic transmission, GABAergicsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch one-carbon metabolic processsearch kidney developmentsearch response to pHsearch regulation of intracellular pHsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch positive regulation of cellular pH reductionsearch regulation of anion transportsearch secretionsearch response to estrogensearch response to steroid hormonesearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch positive regulation of osteoclast differentiationsearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch positive regulation of bone resorptionsearch metal ion bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch