› 4e42

X-ray diffraction
2.7Å resolution

Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4

Released:
DOI: 10.2210/pdb4e42/pdb
PDB entry 4e42 coloured by chain, front view.
PDB entry 4e42 coloured by chain, side view.
PDB entry 4e42 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Deng L, Langley RJ, Wang Q, Topalian SL, Mariuzza RA
Proc. Natl. Acad. Sci. U.S.A. (2012)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213455 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
T cell receptor G4 alpha chain Chains: A, C
Molecule details ›
Chains: A, C
Length: 203 amino acids
Theoretical weight: 22.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins
T cell receptor G4 beta chain Chains: B, D
Molecule details ›
Chains: B, D
Length: 239 amino acids
Theoretical weight: 27.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand CL 9 x CL
Ligand NO3 2 x NO3
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2
Unit cell:
a: 168.07Å b: 75.365Å c: 130.859Å
α: 90° β: 123.48° γ: 90°
R-values:
R R work R free
0.203 0.2 0.263
Expression system: Escherichia coli

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