4e41 Summary details

pdbe.org/4e41/summary_details
spacer Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Summary
Header IMMUNE SYSTEMsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.6 Å, R-factor: 20.076%, Free R-factor: 26.374%, Spacegroup: C 1 2 1
Released 29/08/2012, deposition: 11/03/2012, last revision: 29/08/2012
Authors Deng, L.search; Langley, R.J.search; Wang, Q.search; Topalian, S.L.search; Mariuzza, R.A.search
Primary citation Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
PROC.NATL.ACAD.SCI.USAsearch (2012)
Keywords Ig domainsearch, adaptive immunitysearch, T cell receptorsearch, MHCsearch, IMMUNE SYSTEMsearch
EC 5.3.1.1 ExPASy BRENDA search (H C)
Organism Homo sapiens(human) 9606search(A F B G C H D I E J)
UniProt P01903search (A F)
P04229search (B G)
P60174search (C H)
Solvent A, B, C, D, E, F, G, H, I, J
Related entries 4e42
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, F HLA class II histocompatibility antigen, DR alpha chain Protein P01903 (DRA_HUMAN)search
182 98%
B, G HLA class II histocompatibility antigen, DRB1-1 beta chain Protein P04229 (2B11_HUMAN)search
190 94%
C, H Triosephosphate isomerase Protein P60174 (TPIS_HUMAN)search
15 100%
D, I T cell receptor G4 alpha chain Protein
203 93%
E, J T cell receptor G4 beta chain Protein
239 99%
Heterogens
Chain Id Name Ligands
A, B SODIUM ION NA search
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