4e41 Summary

pdbe.org/4e41
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Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4

The structure was published by Deng, L., Langley, R.J., Wang, Q., Topalian, S.L., and Mariuzza, R.A., in 2012 in a paper entitled "Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This entry contains 22 copies of 5 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A HLA class II histocompatibility antigen, DR alpha chain P01903 (26-207) (DRA_HUMAN)search Homo sapienssearch < 90% 182 98%
F HLA class II histocompatibility antigen, DR alpha chain P01903 (26-207) (DRA_HUMAN)search Homo sapienssearch < 90% 182 98%
B HLA class II histocompatibility antigen, DRB1-1 beta chain P04229 (30-219) (2B11_HUMAN)search Homo sapienssearch < 90% 190 94%
G HLA class II histocompatibility antigen, DRB1-1 beta chain P04229 (30-219) (2B11_HUMAN)search Homo sapienssearch < 90% 190 94%
C Triosephosphate isomerase P60174 (60-74) (TPIS_HUMAN)search Homo sapienssearch < 90% 15 100%
H Triosephosphate isomerase P60174 (60-74) (TPIS_HUMAN)search Homo sapienssearch < 90% 15 100%
D T cell receptor G4 alpha chain Not available
Homo sapienssearch Not available 203 93%
I T cell receptor G4 alpha chain Not available
Homo sapienssearch Not available 203 93%
E T cell receptor G4 beta chain Not available
Homo sapienssearch Not available 239 99%
J T cell receptor G4 beta chain Not available
Homo sapienssearch Not available 239 99%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01903 (26 - 207) HLA class II histocompatibility antigen, DR alpha chain Homo sapiens
P04229 (30 - 219) HLA class II histocompatibility antigen, DRB1-1 beta chain Homo sapiens
P60174 (60 - 74) Triosephosphate isomerase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, F Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, alpha domainsearch, Immunoglobulin C1-set domainsearch
B, G Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1search, Immunoglobulinssearch Class II histocompatibility antigen, beta domainsearch, Immunoglobulin C1-set domainsearch
C, H Triosephosphate isomerasesearch
D, I Immunoglobulinssearch
E, J Immunoglobulinssearch

Chain ID Biological process (GO) Cellular component (GO)
A, F (P01903) immune responsesearch antigen processing and presentationsearch membranesearch MHC class II protein complexsearch
B, G (P04229) immune responsesearch antigen processing and presentationsearch membranesearch MHC class II protein complexsearch

Chain InterPro annotation
A, F MHC class II, alpha chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
B, G MHC class II, beta chain, N-terminalsearch Immunoglobulin/major histocompatibility complex, conserved sitesearch Immunoglobulin C1-setsearch Immunoglobulin-like domainsearch MHC classes I/II-like antigen recognition proteinsearch Immunoglobulin-like foldsearch MHC class II, alpha/beta chain, N-terminalsearch
C, H
D, I Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch Domain of unknown function DUF1968search
E, J Immunoglobulin C1-setsearch Immunoglobulin subtypesearch Immunoglobulin-like domainsearch Immunoglobulin V-set domainsearch Immunoglobulin-like foldsearch