spacer Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
CATH: Protein Structure Classification
CATH code 3.10.320.10 search
Domains
4e41A01 , 4e41F01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, f.Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, g. Fragment: unp residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Triosephosphate isomerase.Chain: c, h. Fragment: unp residues 60-74. Synonym: tim, triose-phosphate isomerase. Engineered: yes. T cell receptor g4 alpha chain. Chain:d, i. Engineered: yes. T cell receptor g4 beta chain. Chain: e, j. Engineered: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-drb1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: tpi1, tpi. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers A, F
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
Homologous superfamily Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
 
CATH code 2.60.40.10 search
Domains
4e41A02 , 4e41F02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, f.Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, g. Fragment: unp residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Triosephosphate isomerase.Chain: c, h. Fragment: unp residues 60-74. Synonym: tim, triose-phosphate isomerase. Engineered: yes. T cell receptor g4 alpha chain. Chain:d, i. Engineered: yes. T cell receptor g4 beta chain. Chain: e, j. Engineered: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-drb1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: tpi1, tpi. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers A, F
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 3.10.320.10 search
Domains
4e41B01 , 4e41G01
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, f.Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, g. Fragment: unp residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Triosephosphate isomerase.Chain: c, h. Fragment: unp residues 60-74. Synonym: tim, triose-phosphate isomerase. Engineered: yes. T cell receptor g4 alpha chain. Chain:d, i. Engineered: yes. T cell receptor g4 beta chain. Chain: e, j. Engineered: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-drb1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: tpi1, tpi. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers B, G
Hierarchy
Class Alpha Betasearch
Architecture Roll search
Topology Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
Homologous superfamily Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 search
 
CATH code 2.60.40.10 search
Domains
4e41B02 , 4e41G02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, f.Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, g. Fragment: unp residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Triosephosphate isomerase.Chain: c, h. Fragment: unp residues 60-74. Synonym: tim, triose-phosphate isomerase. Engineered: yes. T cell receptor g4 alpha chain. Chain:d, i. Engineered: yes. T cell receptor g4 beta chain. Chain: e, j. Engineered: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-drb1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: tpi1, tpi. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers B, G
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 2.60.40.10 search
Domains
4e41D01 , 4e41D02 , 4e41I01 , 4e41I02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, f.Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, g. Fragment: unp residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Triosephosphate isomerase.Chain: c, h. Fragment: unp residues 60-74. Synonym: tim, triose-phosphate isomerase. Engineered: yes. T cell receptor g4 alpha chain. Chain:d, i. Engineered: yes. T cell receptor g4 beta chain. Chain: e, j. Engineered: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-drb1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: tpi1, tpi. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers D, I
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
CATH code 2.60.40.10 search
Domains
4e41E01 , 4e41E02 , 4e41J01 , 4e41J02
Name Hla class ii histocompatibility antigen, dr alpha chain. Chain: a, f.Fragment: unp residues 26-207. Synonym: mhc class ii antigen dra. Engineered: yes. Hla class ii histocompatibility antigen, drb1-1 beta chain. Chain: b, g. Fragment: unp residues 30-219. Synonym: mhc class ii antigen drb1*1, dr-1, dr1. Engineered: yes. Triosephosphate isomerase.Chain: c, h. Fragment: unp residues 60-74. Synonym: tim, triose-phosphate isomerase. Engineered: yes. T cell receptor g4 alpha chain. Chain:d, i. Engineered: yes. T cell receptor g4 beta chain. Chain: e, j. Engineered: yes
Source Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-dra, hla-dra1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-drb1. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Human. Organism_taxid: 9606. Gene: tpi1, tpi. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
Polymers E, J
Hierarchy
Class Mainly Betasearch
Architecture Sandwich search
Topology Immunoglobulin-like search
Homologous superfamily Immunoglobulins search
 
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