4e3g Summary


Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors

The structure was published by Martin, D.P. and Cohen, S.M., in 2012 in a paper entitled "Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.55 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) regulation of intracellular pHsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch response to pHsearch positive regulation of dipeptide transmembrane transportsearch regulation of chloride transportsearch one-carbon metabolic processsearch response to estrogensearch kidney developmentsearch response to zinc ionsearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch positive regulation of bone resorptionsearch regulation of anion transportsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch secretionsearch positive regulation of osteoclast differentiationsearch positive regulation of synaptic transmission, GABAergicsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch membranesearch cytoplasmsearch basolateral plasma membranesearch cytosolsearch myelin sheathsearch plasma membranesearch extracellular vesicular exosomesearch apical part of cellsearch microvillussearch axonsearch extracellular spacesearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch