4e3f Summary


Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors

The structure was published by Martin, D.P. and Cohen, S.M., in 2012 in a paper entitled "Nucleophile recognition as an alternative inhibition mode for benzoic acid based carbonic anhydrase inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch lyase activitysearch myelin sheathsearch apical part of cellsearch cytoplasmsearch microvillussearch cytosolsearch extracellular vesicular exosomesearch plasma membranesearch basolateral plasma membranesearch axonsearch membranesearch extracellular spacesearch morphogenesis of an epitheliumsearch response to zinc ionsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch regulation of intracellular pHsearch response to estrogensearch one-carbon metabolic processsearch small molecule metabolic processsearch bicarbonate transportsearch positive regulation of cellular pH reductionsearch regulation of chloride transportsearch positive regulation of bone resorptionsearch secretionsearch odontogenesis of dentin-containing toothsearch kidney developmentsearch response to pHsearch response to steroid hormonesearch response to organic substancesearch regulation of anion transportsearch positive regulation of synaptic transmission, GABAergicsearch angiotensin-activated signaling pathwaysearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch