› 4e1z

X-ray diffraction
2.5Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193087 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Non-receptor tyrosine-protein kinase TYK2 Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.7 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9R117 (Residues: 884-1174; Coverage: 25%)
Gene name: Tyk2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 0MX 1 x 0MX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P3121
Unit cell:
a: 68.03Å b: 68.03Å c: 152.999Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.197 0.237
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene.
Leitner et al. (2017)
1 more

1 mention without citation

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.
Argiriadi et al. (2012)