4e1z Summary


Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor

The structure was published by Argiriadi, M.A., Goedken, E.R., Banach, D., et al., Wishart, N., Woller, K., and Talanian, R.V., in 2012 in a paper entitled "Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Non-receptor tyrosine-protein kinase TYK2. This molecule has the UniProt identifier Q9R117 (TYK2_MOUSE)search. The sample contained 291 residues which is < 90% of the natural sequence. Out of 291 residues 287 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Non-receptor tyrosine-protein kinase TYK2 Q9R117 (880-1170) (TYK2_MOUSE)search Mus musculussearch < 90% 291 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9R117 (880 - 1170) Non-receptor tyrosine-protein kinase TYK2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q9R117) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch