Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
The structure was published by Argiriadi, M.A., Goedken, E.R., Banach, D., et al., Wishart, N., Woller, K., and Talanian, R.V., in 2012 in a paper entitled "Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2012.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Non-receptor tyrosine-protein kinase TYK2. This molecule has the UniProt identifier Q9R117 (TYK2_MOUSE). The sample contained 291 residues which is < 90% of the natural sequence. Out of 291 residues 287 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: