4e1g Summary

pdbe.org/4e1g
spacer

X-ray crystal structure of alpha-linolenic acid bound to the cyclooxygenase channel of cyclooxygenase-2

The structure was published by Vecchio, A.J., Orlando, B.J., Nandagiri, R., and Malkowski, M.G., in 2012 in a paper entitled "Investigating Substrate Promiscuity in Cyclooxygenase-2: THE ROLE OF ARG-120 AND RESIDUES LINING THE HYDROPHOBIC GROOVE." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Prostaglandin G/H synthase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Prostaglandin G/H synthase 2 Q05769 (1-19) (PGH2_MOUSE)search ,
Q05769 (20-604) (PGH2_MOUSE)search
Mus musculussearch ,
Mus musculussearch
94% ,
94%
610 90%
B Prostaglandin G/H synthase 2 Q05769 (1-19) (PGH2_MOUSE)search ,
Q05769 (20-604) (PGH2_MOUSE)search
Mus musculussearch ,
Mus musculussearch
94% ,
94%
610 90%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (1 - 19) Prostaglandin G/H synthase 2 Mus musculus

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (Q05769) Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (Q05769) positive regulation of apoptotic processsearch positive regulation of NF-kappaB import into nucleussearch response to vitamin Dsearch cellular response to ATPsearch prostaglandin biosynthetic processsearch oxidation-reduction processsearch cyclooxygenase pathwaysearch positive regulation of smooth muscle cell proliferationsearch angiogenesissearch negative regulation of cell cyclesearch positive regulation of nitric oxide biosynthetic processsearch bone mineralizationsearch inflammatory responsesearch positive regulation vascular endothelial growth factor productionsearch positive regulation of brown fat cell differentiationsearch maintenance of blood-brain barriersearch response to lithium ionsearch keratinocyte differentiationsearch negative regulation of calcium ion transportsearch cellular response to hypoxiasearch negative regulation of cell proliferationsearch response to cytokinesearch regulation of cell proliferationsearch sensory perception of painsearch negative regulation of synaptic transmission, dopaminergicsearch cellular response to UVsearch hair cyclesearch response to glucocorticoidsearch brown fat cell differentiationsearch positive regulation of fibroblast growth factor productionsearch response to drugsearch response to manganese ionsearch ovulationsearch negative regulation of smooth muscle contractionsearch positive regulation of platelet-derived growth factor productionsearch decidualizationsearch positive regulation of cell deathsearch response to fatty acidsearch regulation of blood pressuresearch positive regulation of synaptic plasticitysearch fatty acid biosynthetic processsearch positive regulation of fever generationsearch positive regulation of synaptic transmission, glutamatergicsearch response to organonitrogen compoundsearch response to organic cyclic compoundsearch memorysearch response to organic substancesearch positive regulation of cell migration involved in sprouting angiogenesissearch positive regulation of smooth muscle contractionsearch positive regulation of transforming growth factor beta productionsearch response to lipopolysaccharidesearch response to tumor necrosis factorsearch response to estradiolsearch learningsearch response to fructosesearch positive regulation of vasoconstrictionsearch fatty acid metabolic processsearch response to radiationsearch lipid metabolic processsearch positive regulation of cell proliferationsearch embryo implantationsearch cellular response to mechanical stimulussearch prostaglandin metabolic processsearch response to oxidative stresssearch prostaglandin-endoperoxide synthase activitysearch dioxygenase activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch enzyme bindingsearch lipid bindingsearch protein homodimerization activitysearch peroxidase activitysearch heme bindingsearch metal ion bindingsearch oxidoreductase activitysearch cytoplasmsearch intracellular membrane-bounded organellesearch caveolasearch endoplasmic reticulumsearch membranesearch protein complexsearch neuron projectionsearch organelle membranesearch endoplasmic reticulum membranesearch

Chain InterPro annotation
A, B Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search