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Evaluation of Synthetic FK506 Analogs as Ligands for the FK506-Binding Proteins 51 and 52: Complex of FKBP51 with 2-(3-((R)-3-(3,4-dimethoxyphenyl)-1-((S)-1-(2-((1R,2S)-2-ethyl-1-hydroxy-cyclohexyl)-2-oxoacetyl)piperidine-2-carbonyloxy)propyl)phenoxy)acetic acid from cocrystallization

Source organism: Homo sapiens
Biochemical function: peptidyl-prolyl cis-trans isomerase activity
Biological process: not assigned
Cellular component: not assigned

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EC 5.2.1.8: Peptidylprolyl isomerase

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Systematic name:
Peptidylproline cis-trans-isomerase
Alternative Name(s):
  • Cyclophilin
  • PPIase
  • Peptide bond isomerase
  • Peptidyl-prolyl cis-trans isomerase
  • Peptidylprolyl cis-trans isomerase
  • Rotamase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00254
Domain description: FKBP-type peptidyl-prolyl cis-trans isomerase
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase FKBP5
The deposited structure of PDB entry 4drp contains 1 copy of Pfam domain PF00254 (FKBP-type peptidyl-prolyl cis-trans isomerase) in Peptidyl-prolyl cis-trans isomerase FKBP5. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001179
Domain description: FKBP-type peptidyl-prolyl cis-trans isomerase domain
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase FKBP5
IPR046357
Domain description: Peptidyl-prolyl cis-trans isomerase domain superfamily
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase FKBP5

Structure domain

CATH CATH domain
3.10.50.40
Class: Alpha Beta
Architecture: Roll
Topology: Chitinase A; domain 3
Homology: Chitinase A; domain 3
Occurring in:
  1. Peptidyl-prolyl cis-trans isomerase FKBP5
The deposited structure of PDB entry 4drp contains 1 copy of CATH domain 3.10.50.40 (Chitinase A; domain 3) in Peptidyl-prolyl cis-trans isomerase FKBP5. Showing 1 copy in chain A.

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