4dkc Summary

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Crystal Structure of Human Interleukin-34

The structure was published by Ma, X., Lin, W.Y., Chen, Y., et al., Martin, F., Bazan, J.F., and Starovasnik, M.A., in 2012 in a paper entitled "Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.85 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Interleukin-34.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Interleukin-34 Q6ZMJ4 (21-193) (IL34_HUMAN)search Homo sapienssearch < 90% 190 84%
B Interleukin-34 Q6ZMJ4 (21-193) (IL34_HUMAN)search Homo sapienssearch < 90% 190 84%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q6ZMJ4 (21 - 193) Interleukin-34 Homo sapiens

Chain Sequence family (Pfam)
A, B Interleukin 34search

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (Q6ZMJ4) extracellular spacesearch positive regulation of protein phosphorylationsearch positive regulation of cell proliferationsearch macrophage colony-stimulating factor receptor bindingsearch

Chain InterPro annotation
A, B Interleukin-34search