4dj9 Summary


Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin binding site 50 (VBS50, residues 2078-2099)

The structure was published by Yogesha, S.D., Rangarajan, E.S., Vonrhein, C., Bricogne, G., and Izard, T., in 2012 in a paper entitled "Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vinculin and Talin-1.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vinculin P18206 (1-258) (VINC_HUMAN)search Homo sapienssearch 94% 258 94%
B Talin-1 Q9Y490 (2075-2103) (TLN1_HUMAN)search Homo sapienssearch < 90% 29 75%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18206 (1 - 258) Vinculin Homo sapiens
Q9Y490 (2075 - 2103) Talin-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P18206) Four Helix Bundle (Hemerythrin (Met), subunit A)search PF01044: Vinculin familysearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P18206) actin cytoskeletonsearch structural molecule activitysearch cell adhesionsearch

Chain InterPro annotation
A Vinculin, conserved sitesearch Vinculin/alpha-cateninsearch Vinculinsearch