4di9 Summary

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PDB entry 4di9 (supersedes 4d9a)

CRYSTAL STRUCTURE OF THE D248A mutant of 2-PYRONE-4,6-DICARBOXYLIC ACID HYDROLASE FROM SPHINGOMONAS PAUCIMOBILIS complexed with substrate at pH 6.5

The structure was published by Hobbs, M.E., Malashkevich, V., Williams, H.J., et al., Burley, S.K., Almo, S.C., and Raushel, F.M., in 2012 in a paper entitled "Structure and Catalytic Mechanism of LigI: Insight into the Amidohydrolase Enzymes of cog3618 and Lignin Degradation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.35 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 2-pyrone-4,6-dicarbaxylate hydrolase. This molecule has the UniProt identifier O87170 (PDCH_SPHPI)search. The sample contained 303 residues which is 100% of the natural sequence. Out of 303 residues 293 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 2-pyrone-4,6-dicarbaxylate hydrolase O87170 (2-293) (PDCH_SPHPI)search Sphingomonas paucimobilissearch 100% 303 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O87170 (2 - 293) 2-pyrone-4,6-dicarbaxylate hydrolase Sphingomonas paucimobilis

Chain Sequence family (Pfam)
A (O87170) PF04909: Amidohydrolasesearch

Chain ID Biological process (GO) Molecular function (GO)
A (O87170) metabolic processsearch protocatechuate catabolic processsearch catalytic activitysearch 2-pyrone-4,6-dicarboxylate lactonase activitysearch hydrolase activitysearch

Chain InterPro annotation
A Amidohydrolase 2search