4dgd Summary


TRIMCyp cyclophilin domain from Macaca mulatta: H70C mutant

The structure was published by Caines, M.E., Bichel, K., Price, A.J., et al., Willett, B.J., Freund, S.M., and James, L.C., in 2012 in a paper entitled "Diverse HIV viruses are targeted by a conformationally dynamic antiviral." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.4 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of TRIMCyp. This molecule has the UniProt identifier P62940 (PPIA_MACMU)search. The sample contained 165 residues which is 100% of the natural sequence. Out of 165 residues 165 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TRIMCyp P62940 (1-165) (PPIA_MACMU)search Macaca mulattasearch 100% 165 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P62940 (1 - 165) TRIMCyp Macaca mulatta

Chain Sequence family (Pfam)
A (P62940) PF00160: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDsearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P62940) protein foldingsearch regulation of viral genome replicationsearch protein peptidyl-prolyl isomerizationsearch cytoplasmsearch cytosolsearch extracellular regionsearch nucleussearch peptidyl-prolyl cis-trans isomerase activitysearch isomerase activitysearch peptide bindingsearch

Chain InterPro annotation
A Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainsearch Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved sitesearch Cyclophilin-type peptidyl-prolyl cis-trans isomerasesearch Cyclophilin-like domainsearch