4dgb Summary


TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex

The structure was published by Caines, M.E., Bichel, K., Price, A.J., et al., Willett, B.J., Freund, S.M., and James, L.C., in 2012 in a paper entitled "Diverse HIV viruses are targeted by a conformationally dynamic antiviral." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.702 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely TRIMCyp and capsid protein.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A TRIMCyp P62940 (1-165) (PPIA_MACMU)search Macaca mulattasearch 100% 165 98%
B capsid protein P04590 (221-226) (GAG_HV2RO)search Human immunodeficiency virus type 2 (ISOLATE ROD)search < 90% 6 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P62940 (1 - 165) TRIMCyp Macaca mulatta
P04590 (221 - 226) capsid protein Human immunodeficiency virus 2

Chain Sequence family (Pfam)
A (P62940) PF00160: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLDsearch
B gag gene protein p24 (core nucleocapsid protein)search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P62940) protein foldingsearch regulation of viral genome replicationsearch protein peptidyl-prolyl isomerizationsearch peptidyl-prolyl cis-trans isomerase activitysearch peptide bindingsearch isomerase activitysearch cytoplasmsearch extracellular regionsearch cytosolsearch nucleussearch

Chain InterPro annotation
A Cyclophilin-type peptidyl-prolyl cis-trans isomerase domainsearch Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved sitesearch Cyclophilin-type peptidyl-prolyl cis-trans isomerasesearch Cyclophilin-like domainsearch