4daj Summary

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Structure of the M3 Muscarinic Acetylcholine Receptor

The structure was published by Kruse, A.C., Hu, J., Pan, A.C., et al., Weis, W.I., Wess, J., and Kobilka, B.K., in 2012 in a paper entitled "Structure and dynamics of the M3 muscarinic acetylcholine receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.4 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Muscarinic acetylcholine receptor M3, Lysozyme.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Muscarinic acetylcholine receptor M3, Lysozyme P00720 (1-161) (ENLYS_BPT4)search ,
P08483 (57-259) (ACM3_RAT)search ,
P08483 (482-589) (ACM3_RAT)search
Enterobacteria phage T4search ,
Rattus norvegicussearch ,
Rattus norvegicussearch
93% ,
< 90% ,
< 90%
479 90%
B Muscarinic acetylcholine receptor M3, Lysozyme P00720 (1-161) (ENLYS_BPT4)search ,
P08483 (57-259) (ACM3_RAT)search ,
P08483 (482-589) (ACM3_RAT)search
Enterobacteria phage T4search ,
Rattus norvegicussearch ,
Rattus norvegicussearch
93% ,
< 90% ,
< 90%
479 90%
C Muscarinic acetylcholine receptor M3, Lysozyme P00720 (1-161) (ENLYS_BPT4)search ,
P08483 (57-259) (ACM3_RAT)search ,
P08483 (482-589) (ACM3_RAT)search
Enterobacteria phage T4search ,
Rattus norvegicussearch ,
Rattus norvegicussearch
93% ,
< 90% ,
< 90%
479 90%
D Muscarinic acetylcholine receptor M3, Lysozyme P00720 (1-161) (ENLYS_BPT4)search ,
P08483 (57-259) (ACM3_RAT)search ,
P08483 (482-589) (ACM3_RAT)search
Enterobacteria phage T4search ,
Rattus norvegicussearch ,
Rattus norvegicussearch
93% ,
< 90% ,
< 90%
479 90%


Chain Sequence family (Pfam)
A, B, C, D (P00720) PF00959: Phage lysozymesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (P08483P00720) positive regulation of smooth muscle contractionsearch cell wall macromolecule catabolic processsearch G-protein coupled receptor signaling pathwaysearch metabolic processsearch cytolysissearch saliva secretionsearch peptidoglycan catabolic processsearch viral release from host cellsearch defense response to bacteriumsearch lysozyme activitysearch G-protein coupled acetylcholine receptor activitysearch G-protein coupled receptor activitysearch catalytic activitysearch hydrolase activitysearch hydrolase activity, acting on glycosyl bondssearch host cell cytoplasmsearch integral component of membranesearch integral component of plasma membranesearch

Chain InterPro annotation
A, B, C, D G protein-coupled receptor, rhodopsin-likesearch Bacteriophage T4, Gp5, tail-associated lysozymesearch Muscarinic acetylcholine receptor M3search Glycoside hydrolase, family 24search GPCR, rhodopsin-like, 7TMsearch Lysozyme-like domainsearch Lysozyme domainsearch