4da5 Summary


Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology

The structure was published by Hudson, C.S., Knegtel, R.M., Brown, K., Charlton, P.A., and Pollard, J.R., in 2013 in a paper entitled "Kinetic and mechanistic characterisation of Choline Kinase-alpha." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Choline kinase alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Choline kinase alpha P35790 (1-457) (CHKA_HUMAN)search Homo sapienssearch 100% 457 77%
B Choline kinase alpha P35790 (1-457) (CHKA_HUMAN)search Homo sapienssearch 100% 457 77%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P35790 (1 - 457) Choline kinase alpha Homo sapiens

Chain Sequence family (Pfam)
A, B (P35790) PF01633: Choline/ethanolamine kinasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P35790) transferase activity, transferring phosphorus-containing groupssearch transferase activitysearch signal transducer activitysearch nucleotide bindingsearch choline kinase activitysearch drug bindingsearch protein homodimerization activitysearch ATP bindingsearch ethanolamine kinase activitysearch cholinesterase activitysearch kinase activitysearch choline bindingsearch phospholipid metabolic processsearch phosphatidylethanolamine biosynthetic processsearch phosphatidylcholine biosynthetic processsearch CDP-choline pathwaysearch lipid metabolic processsearch choline metabolic processsearch signal transductionsearch glycerophospholipid biosynthetic processsearch lipid transportsearch phospholipid biosynthetic processsearch small molecule metabolic processsearch phosphorylationsearch cytosolsearch cytoplasmsearch

Chain InterPro annotation
A, B Protein kinase-like domainsearch