Structure analysis

Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology

X-ray diffraction
2.4Å resolution
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo dimer
Accessible surface area: 32020.9 Å2
Buried surface area: 2928.3 Å2
Dissociation area: 1,239.21 Å2
Dissociation energy (ΔGdiss): 5.85 kcal/mol
Dissociation entropy (TΔSdiss): 14.04 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-153023

Macromolecules

Chains: A, B
Length: 457 amino acids
Theoretical weight: 52.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35790 (Residues: 1-457; Coverage: 100%)
Gene names: CHK, CHKA, CKI
Pfam: Choline/ethanolamine kinase
InterPro: Protein kinase-like domain superfamily
CATH:

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