4cak

Electron Microscopy
20.5Å resolution

Three-dimensional reconstruction of intact human integrin alphaIIbbeta3 in a phospholipid bilayer nanodisc

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-138441 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Integrin alpha-IIb Chain: A
Molecule details ›
Chain: A
Length: 959 amino acids
Theoretical weight: 104.46 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P08514 (Residues: 32-990; Coverage: 95%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains:
Integrin beta-3 Chain: B
Molecule details ›
Chain: B
Length: 690 amino acids
Theoretical weight: 76.32 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P05106 (Residues: 27-716; Coverage: 91%)
Gene names: GP3A, ITGB3
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 20.5Å
Relevant EMDB volumes: EMD-2281