4bxo Summary

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Architecture and DNA recognition elements of the Fanconi anemia FANCM- FAAP24 complex

The structure was published by Coulthard, R., Deans, A.J., Swuec, P., et al., Costa, A., West, S.C., and Mcdonald, N.Q., in 2013 in a paper entitled "Architecture and DNA Recognition Elements of the Fanconi Anemia Fancm-Faap24 Complex." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.15 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This entry contains 12 copies of 4 unique biopolymers (complete list).

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FANCONI ANEMIA GROUP M PROTEIN Q8IYD8 (1798-2048) (FANCM_HUMAN)search Homo sapienssearch < 90% 254 79%
B FANCONI ANEMIA-ASSOCIATED PROTEIN OF 24 KDA Q9BTP7 (1-214) (FAP24_HUMAN)search Homo sapienssearch 93% 217 90%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8IYD8 (1798 - 2048) FANCONI ANEMIA GROUP M PROTEIN Homo sapiens
Q9BTP7 (1 - 214) FANCONI ANEMIA-ASSOCIATED PROTEIN OF 24 KDA Homo sapiens

Chain Sequence family (Pfam)
A ERCC4 domainsearch
B (Q9BTP7) PF12826: Helix-hairpin-helix motifsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (Q8IYD8) nuclease activitysearch DNA bindingsearch DNA metabolic processsearch
B (Q9BTP7) DNA bindingsearch protein bindingsearch chromatin bindingsearch DNA repairsearch cellular response to DNA damage stimulussearch Fanconi anaemia nuclear complexsearch nucleussearch nucleolussearch nucleoplasmsearch intracellular membrane-bounded organellesearch

Chain InterPro annotation
A ERCC4 domainsearch RuvA domain 2-likesearch Restriction endonuclease type II-likesearch DNA repair nuclease, XPF-type/Helicasesearch
B RuvA domain 2-likesearch Fanconi anemia-associated protein of 24kDasearch