4buz Summary

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SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD

The structure was published by Gertz, M., Fischer, F., Nguyen, G.T.T., et al., Schutkowski, M., Weyand, M., and Steegborn, C., in 2013 in a paper entitled "Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely NAD-DEPENDENT PROTEIN DEACETYLASE and CELLULAR TUMOR ANTIGEN P53.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A NAD-DEPENDENT PROTEIN DEACETYLASE Q9WYW0 (1-246) (NPD_THEMA)search Thermotoga maritima MSB8search 100% 246 96%
P CELLULAR TUMOR ANTIGEN P53 P04637 (379-386) (P53_HUMAN)search Homo sapienssearch < 90% 8 87%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q9WYW0 (1 - 246) NAD-DEPENDENT PROTEIN DEACETYLASE Thermotoga maritima
P04637 (379 - 386) CELLULAR TUMOR ANTIGEN P53 HOMO SAPIENS

Chain Sequence family (Pfam)
A (Q9WYW0) PF02146: Sir2 familysearch
P

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q9WYW0) protein-succinyllysine desuccinylase activitysearch NAD+ bindingsearch protein-malonyllysine demalonylase activitysearch NAD bindingsearch metal ion bindingsearch hydrolase activitysearch zinc ion bindingsearch NAD-dependent protein deacetylase activitysearch cytoplasmsearch protein deacetylationsearch

Chain InterPro annotation
A Sirtuin familysearch Sirtuin family, catalytic core domainsearch Sirtuin family, catalytic core small domainsearch Sirtuin, class Usearch DHS-like NAD/FAD-binding domainsearch
P