SIR2 COMPLEX STRUCTURE MIXTURE OF EX-527 INHIBITOR AND REACTION PRODUCTS OR OF REACTION SUBSTRATES P53 PEPTIDE AND NAD
The structure was published by Gertz, M., Fischer, F., Nguyen, G.T.T., et al., Schutkowski, M., Weyand, M., and Steegborn, C., in 2013 in a paper entitled "Ex-527 Inhibits Sirtuins by Exploiting Their Unique Nad+-Dependent Deacetylation Mechanism" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.9 Å and deposited in 2013.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 2 biomacromolecules, namely NAD-DEPENDENT PROTEIN DEACETYLASE and CELLULAR TUMOR ANTIGEN P53.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterodimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 2 unique UniProt proteins: