Function and Biology

Legionella pneumophila NTPDase1 N302Y variant crystal form III (closed) in complex with MG UMPPNP

Source organism: Legionella pneumophila
Biochemical function: metal ion binding
Biological process: not assigned
Cellular component: not assigned

EC 3.6.1.5: Apyrase

Reaction catalysed:
(1a) a nucleoside 5'-triphosphate + H(2)O = a nucleoside 5'-diphosphate + phosphate
Systematic name:
Nucleoside triphosphate phosphohydrolase (nucleoside monophosphoate-forming)
Alternative Name(s):
  • ADPase
  • ATP diphosphohydrolase
  • ATP-diphosphatase
  • ATP-diphosphohydrolase
  • Adenosine diphosphatase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF01150
Domain description: GDA1/CD39 (nucleoside phosphatase) family
Occurring in:
  1. Ectonucleoside triphosphate diphosphohydrolase I
The deposited structure of PDB entry 4brk contains 4 copies of Pfam domain PF01150 (GDA1/CD39 (nucleoside phosphatase) family) in Ectonucleoside triphosphate diphosphohydrolase I. Showing 2 copies in chain B.

InterPro InterPro annotation
IPR000407
Domain description: Nucleoside phosphatase GDA1/CD39
Occurring in:
  1. Ectonucleoside triphosphate diphosphohydrolase I

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Ectonucleoside triphosphate diphosphohydrolase I
The deposited structure of PDB entry 4brk contains 2 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Ectonucleoside triphosphate diphosphohydrolase I. Showing 1 copy in chain B.
3.30.420.150
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Exopolyphosphatase. Domain 2
Occurring in:
  1. Ectonucleoside triphosphate diphosphohydrolase I
The deposited structure of PDB entry 4brk contains 2 copies of CATH domain 3.30.420.150 (Nucleotidyltransferase; domain 5) in Ectonucleoside triphosphate diphosphohydrolase I. Showing 1 copy in chain B.