4bnt Summary

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Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2-(trifluoromethyl)-1H- benzimidazole at 2.3A resolution

The structure was published by Cukier, C.D., Hope, A., Elamin, A., et al., Lindqvist, Y., Gray, D., and Schneider, G., in 2013 in a paper entitled "Discovery of an Allosteric Inhibitor Binding Site in 3-Oxo-Acyl-Acp Reductase from Pseudomonas Aeruginosa" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2013.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG O54438 (1-247) (FABG_PSEAE)search Pseudomonas aeruginosa PAO1search 100% 269 89%
B 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG O54438 (1-247) (FABG_PSEAE)search Pseudomonas aeruginosa PAO1search 100% 269 89%
C 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG O54438 (1-247) (FABG_PSEAE)search Pseudomonas aeruginosa PAO1search 100% 269 89%
D 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG O54438 (1-247) (FABG_PSEAE)search Pseudomonas aeruginosa PAO1search 100% 269 89%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O54438 (1 - 247) 3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG Pseudomonas aeruginosa PAO1

Chain Sequence family (Pfam)
A, B, C, D (O54438) PF00106: short chain dehydrogenasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B, C, D (O54438) fatty acid biosynthetic processsearch metabolic processsearch lipid metabolic processsearch fatty acid elongationsearch oxidation-reduction processsearch fatty acid metabolic processsearch 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activitysearch oxidoreductase activitysearch NAD bindingsearch NADP bindingsearch

Chain InterPro annotation
A, B, C, D Short-chain dehydrogenase/reductase SDRsearch Glucose/ribitol dehydrogenasesearch 3-oxoacyl-(acyl-carrier-protein) reductasesearch NAD(P)-binding domainsearch Short-chain dehydrogenase/reductase, conserved sitesearch