Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor
The structure was published by Langdon, S.R., Westwood, I.M., Van Montfort, R.L.M., Brown, N., and Blagg, J., in 2013 in a paper entitled "Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of Ttk Inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.84 Å and deposited in 2013.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of DUAL SPECIFICITY PROTEIN KINASE TTK. This molecule has the UniProt identifier P33981 (TTK_HUMAN). The sample contained 313 residues which is < 90% of the natural sequence. Out of 313 residues 246 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: