4bcw Summary


Carbonic anhydrase IX mimic in complex with (E)-2-(5-bromo-2- hydroxyphenyl)ethenesulfonic acid

The structure was published by Tars, K., Vullo, D., Kazaks, A., et al., Zalubovskis, R., Scozzafava, A., and Supuran, C.T., in 2013 in a paper entitled "Sulfocoumarins (1,2-Benzoxathiine-2,2-Dioxides): A Class of Potent and Isoform-Selective Inhibitors of Tumor-Associated Carbonic Anhydrases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.5 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of CARBONIC ANHYDRASE 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 257 residues which is 99% of the natural sequence. Out of 257 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CARBONIC ANHYDRASE 2 P00918 (4-260) (CAH2_HUMAN)search Homo sapienssearch 98% 257 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (4 - 260) CARBONIC ANHYDRASE 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) response to pHsearch morphogenesis of an epitheliumsearch carbon dioxide transportsearch regulation of anion transportsearch regulation of intracellular pHsearch bicarbonate transportsearch angiotensin-activated signaling pathwaysearch response to estrogensearch small molecule metabolic processsearch response to steroid hormonesearch positive regulation of osteoclast differentiationsearch secretionsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch positive regulation of dipeptide transmembrane transportsearch kidney developmentsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch response to zinc ionsearch extracellular vesicular exosomesearch cytosolsearch cytoplasmsearch apical part of cellsearch basolateral plasma membranesearch microvillussearch plasma membranesearch axonsearch membranesearch extracellular spacesearch lyase activitysearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch