4b3y Summary

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Cryo-EM Structure of the Mycobacterial Fatty Acid Synthase

The structure was published by Boehringer, D., Ban, N., and Leibundgut, M., in 2013 in a paper entitled "7.5-A Cryo-Em Structure of the Mycobacterial Fatty Acid Synthase." (abstract).

The structure was determined using Electron microscopy at a resolution of 7.5 Å and deposited in 2012.

The experimental data on which the structure is based was deposited separately in EMDB as entry 2238.

This PDB entry contains multiple copies of the structure of FATTY ACID SYNTHASE.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homotrimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A FATTY ACID SYNTHASE A0R1H7 (1-3089) (A0R1H7_MYCS2)search Mycobacterium smegmatis str. MC2 155search 100% 3089 91%
B FATTY ACID SYNTHASE A0R1H7 (1-3089) (A0R1H7_MYCS2)search Mycobacterium smegmatis str. MC2 155search 100% 3089 91%
C FATTY ACID SYNTHASE A0R1H7 (1-3089) (A0R1H7_MYCS2)search Mycobacterium smegmatis str. MC2 155search 100% 3089 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
A0R1H7 (1 - 3089) FATTY ACID SYNTHASE Mycobacterium smegmatis str. MC2 155

Chain Sequence family (Pfam)
A, B, C (A0R1H7) PF00109: Beta-ketoacyl synthase, N-terminal domainsearch, PF00698: Acyl transferase domainsearch, PF01575: MaoC like domainsearch, PF02801: Beta-ketoacyl synthase, C-terminal domainsearch, PF08354: Domain of unknown function (DUF1729)search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C (A0R1H7) catalytic activitysearch fatty acid synthase activitysearch enoyl-[acyl-carrier-protein] reductase (NADH) activitysearch transferase activitysearch nucleotide bindingsearch metabolic processsearch fatty acid biosynthetic processsearch oxidation-reduction processsearch fatty acid synthase complexsearch

Chain InterPro annotation
A, B, C Acyl transferase domainsearch MaoC-like domainsearch Fatty acid synthasesearch Domain of unknown function DUF1729search Aldolase-type TIM barrelsearch Beta-ketoacyl synthase, N-terminalsearch Beta-ketoacyl synthase, C-terminalsearch Acyl transferasesearch Acyl transferase/acyl hydrolase/lysophospholipasesearch Thiolase-like, subgroupsearch Thiolase-likesearch NAD(P)-binding domainsearch HotDog domainsearch