4ay9 Summary

pdbe.org/4ay9
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Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor

The structure was published by Jiang, X., Liu, H., Chen, X., et al., Yu, H.N., Arkinstall, S., and He, X., in 2012 in a paper entitled "Structure of Follicle-Stimulating Hormone in Complex with the Entire Ectodomain of its Receptor." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2012.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDE, FOLLITROPIN SUBUNIT BETA, and FOLLICLE-STIMULATING HORMONE RECEPTOR.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDE P01215 (25-116) (GLHA_HUMAN)search Homo sapienssearch 100% 92 96%
D GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDE P01215 (25-116) (GLHA_HUMAN)search Homo sapienssearch 100% 92 96%
G GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDE P01215 (25-116) (GLHA_HUMAN)search Homo sapienssearch 100% 92 96%
B FOLLITROPIN SUBUNIT BETA P01225 (19-129) (FSHB_HUMAN)search Homo sapienssearch 100% 111 96%
E FOLLITROPIN SUBUNIT BETA P01225 (19-129) (FSHB_HUMAN)search Homo sapienssearch 100% 111 96%
H FOLLITROPIN SUBUNIT BETA P01225 (19-129) (FSHB_HUMAN)search Homo sapienssearch 100% 111 96%
X FOLLICLE-STIMULATING HORMONE RECEPTOR P23945 (17-366) (FSHR_HUMAN)search Homo sapienssearch < 90% 350 87%
Y FOLLICLE-STIMULATING HORMONE RECEPTOR P23945 (17-366) (FSHR_HUMAN)search Homo sapienssearch < 90% 350 87%
Z FOLLICLE-STIMULATING HORMONE RECEPTOR P23945 (17-366) (FSHR_HUMAN)search Homo sapienssearch < 90% 350 87%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
P01215 (25 - 116) GLYCOPROTEIN HORMONES, ALPHA POLYPEPTIDE Homo sapiens
P01225 (19 - 129) FOLLITROPIN SUBUNIT BETA Homo sapiens
P23945 (17 - 366) FOLLICLE-STIMULATING HORMONE RECEPTOR Homo sapiens

Chain Sequence family (Pfam)
A, D, G (P01215) PF00236: Glycoprotein hormonesearch
B, E, H (P01225) PF00007: Cystine-knot domainsearch
X, Y, Z Leucine rich repeat N-terminal domainsearch, Gonadotropin hormone receptor transmembrane regionsearch, Leucine rich repeatsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, D, G (P01215) protein bindingsearch hormone activitysearch extracellular regionsearch thyroid hormone generationsearch developmental growthsearch positive regulation of transcription from RNA polymerase II promotersearch cell-cell signalingsearch cellular response to hormone stimulussearch cellular protein metabolic processsearch positive regulation of cell proliferationsearch follicle-stimulating hormone secretionsearch gonad developmentsearch luteinizing hormone secretionsearch thyroid gland developmentsearch peptide hormone processingsearch negative regulation of organ growthsearch positive regulation of cell migrationsearch signal transductionsearch
B, E, H (P01225) hormone activitysearch protein bindingsearch extracellular regionsearch extracellular vesicular exosomesearch cytoplasmsearch transforming growth factor beta receptor signaling pathwaysearch Sertoli cell proliferationsearch positive regulation of cell migrationsearch cellular protein metabolic processsearch ovarian follicle developmentsearch positive regulation of bone resorptionsearch positive regulation of transcription from RNA polymerase II promotersearch female gamete generationsearch peptide hormone processingsearch positive regulation of cell proliferationsearch female pregnancysearch follicle-stimulating hormone signaling pathwaysearch signal transductionsearch regulation of osteoclast differentiationsearch progesterone biosynthetic processsearch
X, Y, Z (P23945) follicle-stimulating hormone receptor activitysearch protein-hormone receptor activitysearch integral component of membranesearch G-protein coupled receptor signaling pathwaysearch

Chain InterPro annotation
A, D, G Glycoprotein hormone alpha chainsearch Cystine-knot cytokinesearch
B, E, H Gonadotropin, beta subunitsearch Glycoprotein hormone subunit beta, cystine knotsearch Gonadotropin, beta subunit, conserved sitesearch Cystine-knot cytokinesearch
X, Y, Z Leucine-rich repeat-containing N-terminalsearch Leucine-rich repeatsearch Glycoprotein hormone receptor familysearch Follicle stimulating hormone receptorsearch Gonadotropin hormone receptor, transmembrane domainsearch